Abstract: The aim of this paper is to review the extent to which Human Factors methods are able to analyse complex accidents that involve the interaction of multiple systems. The case of the Black Hawk Friendly Fire Shoot Down is taken as it exemplified a System of Systems incident, comprising Black Hawk helicopters, the F-15 jets, the AWACS and the TAOR. The emergent behaviour from the interaction of multiple systems is difficult to anticipate and can have disastrous consequences. The four Human Factors methods applied to the examination of Black Hawk Friendly Fire Shoot Down were AcciMaps, Human Factors Analysis Classification System (HFACS), Systems Theory Accident Model and Process (STAMP) and Event Analysis of Systemic Teamwork (EAST). The analysis shows that the four methods are judged to perform differently across eleven evaluation criteria. In conclusion, the EAST method appears to perform best of the four methods. Future research should seek to establish which of the System of Systems methods could be used for both retrospective analysis (i.e., after an accident has occurred) as well as prospective analysis (i.e., to predict the resilience of systems to accidents).